Seminar Title: “Engineering the intestinal mucosa – in vitro and computational models to enable effective oral drug delivery”
Wednesday, December 7, 2022 from 3:30 – 4:30 PBB 131
Research Lab:
The Advanced Drug Delivery Research (ADDRES) Laboratory at Northeastern University is headed by Dr. Rebecca Carrier of Northeastern’s Department of Chemical Engineering.
The ADDRES Lab studies interactions between materials and biological systems, with a current focus on the intestinal environment, via development of theoretical and tissue-engineered cell culture models. Computational models (molecular and macroscopic) predict what drug delivery systems will enhance absorption of a compound with specific physical and chemical properties. Macroscopic systems-based models of the intestinal drug delivery environment are in the form of mass balances and kinetic equations describing drug release, dissolution, precipitation, and absorption. Mechanistic studies are conducted to enhance fundamental understanding of these processes. Our tissue engineering focus is on developing a biomimetic scaffold with crypt-villus structure for intestinal epithelial cell culture.
For more information, contact: Deirdre McAvoy at deirdre.mcavoy@uconn.edu