VIRTUAL Molecular Biology and Biochemistry Journal Club
Presenter: Amit Luthra
Author & Journal Info: Tsutsumi, K., Yonehara, R., Ishizaka-Ikeda, E. et al. Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun 10, 1520 (2019).
Here is the link: https://doi.org/10.1038/s41467-019-09463-9
Brief Description:Gram-negative bacteria have an outer membrane and an inner membrane. They express several types of tripartite efflux pumps that penetrate both membranes and release foreign substances. Overexpression of efflux pumps is a primary cause of multidrug resistance. Based on a high-resolution Cryo-EM structure, the authors propose a mechanism for drug release.
Time: Noon
Remote Access: Blackboard Collaborate
Link: https://us.bbcollab.com/guest/28fdd26aed0743c6b97d89a2fa477637
Instructions:
- When you click on the link for the first time, you will be prompted to test your microphone and video in your computer/browser. Please try to join the session a few minutes earlier.
- Once you join the session, please mute your microphone using the audio icon at the bottom of the Collaborate screen to minimize the background noise.
- When you want to ask a question during the presentation, please “raise your hand” using the “hand” icon at the bottom of the screen. Once the presenter see it, he/she will ask you speak up. Then you should turn on your microphone, speak and mute afterwards.
- During the presentation, you can also share your comments with other participants using the “chat” function in the Collaborate Panel Menu (the purple arrow sign at the bottom right of the screen).
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For more information, contact: Shanaz Mohamad - Molecular Biology and Biophysics at 860-679-2885 - mohamad@uchc.edu