Presenter: Alison A. Motsinger-Reif, Ph.D., Core Director, Statistical Service Core, North Carolina State University
Title: “Cell Line Models of Cytotoxic Response - Integration of Statistical Methods Development and Genetic Association Mapping”
Abstract: The investigation and discovery of genetic factors that determine differential drug response is the fundamental goals of pharmacogenomics. Practical and ethical limitations studying cytotoxics in either application have motivated the use of lymphoblastoid cell line model(s) for high throughput genetic association studies. We present the results of genome-wide association mapping studies for a large number of commonly used chemotherapy agents, along with the methods development studies behind the high throughput mapping. This GWAS screen produced interesting potential candidate genes, and we present initial results of functional/clinical follow-up of these candidates. We will also present the initial results of clinical validation results from top candidates. These results demonstrate an integrated approach to bioinformatics methods development and application.
1:00 this afternoon
The Jackson Laboratory for Genomic Medicine Leo Holt Conference Room
Hosts: Dr. Peter Robinson, Professor; Dr. Derya Unutmaz, Professor
For more information, contact: Catherine Gallo at catherine.gallo@jax.org