Presenter: Do-Hyun Nam, Professor of the Department of Neurosurgery, Samsung Medical Center, Seoul, Sungkyunkwan University School of Medicine, South Korea
Location: The Jackson Laboratory for Genomic Medicine Leo Holt Conference Room
Time: 1:00 pm
Title: “Precision Oncology Based on the Gene-drug Prediction AVATAR System”
Abstract:Cancer is heterogeneous diseases along with genomic alternations have great variety in an individual patient. Thus, cancer therapy is moving towards precision oncology. Advances in genomics are now being used effectively in oncology. However, the gap between genomic alterations and its clinical features has not been addressed due to a limited model system. We have developed a patient derived AVATAR System which is composed of the AVATAR library containing the patient tissues and patient derived cells (PDCs), an automatic drug screening using genomically characterized PDCs, named AVATASCAN® . It is a new interface concept among genomics, drug screeing and a patient treatement for precision ocology and patient derived xenograft (PDX) model system, called AVATAR Mouse®.
Using a developed AVATAR System, we have established the proof-of-principle of the gene-drug response prediction model. It provides several novel insights into designation underlying the particularly targeted cancer drugs in the most vulnerable population as a personalized treatment and advanced level of drug development. Taken together, our AVATAR System will give a strong experimental background for preclinically and translationally personalized research.
For more information, contact: Jee Young Kwon at jeeyoung.kwon@jax.org