Presenter: Charles Y. Lin, Ph.D., Assistant Professor, Pew Steward Scholar for Cancer Research, Department of Molecular and Human Genetics, Dan L. Duncan Cancer Center, Baylor College of Medicine
Title: “Targeting transcriptional regulation in Myc deregulated cancers”
Abstract: Myc deregulation is a hallmark of cancer and promotes tumor aggression across multiple tumor types. When deregulated, levels of the full length Myc (MYC, MYCN, or MYCL) transcription factor are drastically increased, leading to a global remodeling of gene expression that is poorly understood. Here we show evidence for and propose “Myc enhancer invasion” as a novel mechanism in which excess Myc protein invades distal cis-regulatory enhancers that are not normally bound at physiological Myc levels. As enhancers control tissue specific gene expression, Myc invasion creates aberrant regulatory interactions that drive tumor progression and can be targeted as a therapeutic strategy.
3:00 to 4:00 this afternoon
The Jackson Laboratory for Genomic Medicine Auditorium
Host: Dr. Roel Verhaak
For more information, contact: Eileen King at eileen.king@jax.org