Biomolecular NMR Spectroscopy MCB 5076 (Fall 2020)
Time: Thursdays 2:00-3:15, online course for 2020
Two credits
Enrollment is open to grads & advanced undergrads
TOPICS:
NMR theory Multidimensional NMR Drug screening
NMR assignments NMR structure determination Protein folding
Protein Dynamics Molecular interactions Metabolomics
The course covers NMR (nuclear magnetic resonance) theory, with an emphasis on the
applications of the technique to determining protein structure and dynamics. Starting from the
principles of NMR spectroscopy, we move to the two- and three-dimensional NMR experiments
used to assign resonances to specific atoms. Next, we focus on methods to interrogate “spin
spies” about molecular structure and complementary information on dynamics. The last part of
the course describes advanced NMR applications such as protein folding studies, metabolomics,
amyloids, membrane proteins, and drug discovery.
Course grade: quizzes, specialized assignments for the online version of the course and a takehome
final where students write a report on an NMR paper from the scientific literature.
For more information contact Prof. Alexandrescu at: andrei.alexandrescu@uconn.edu
For more information, contact: Andrei Alexandrescu at andrei.alexandrescu@uconn.edu