Seminar Title: “Progress Toward Real Time Pharmaceutical Lyophilization Process Control”
Wednesday, March 1, 2023 from 3:30 – 4:30 PBB 131
Bio sketch:
Bill Kessler received his bachelor’s and master’s degrees in chemistry from Boston University in 1984 and 1986, performing ultra-high resolution gas spectroscopy research focused on multi-photon excitation of aligned ionic states. In 1986, Bill joined Physical Sciences Inc. in Andover, Massachusetts as a staff scientist. His work at PSI has spanned numerous disciplines including combustion, atmospheric science, chemical laser development and industrial sensor development research. In 2000, he was a co-founder and Director of Applications of a PSI spinout company, Confluent Photonics, focused on the development of silicon-on-insulator photonic waveguides for the telecommunications industry. Years later Bill returned to PSI to focus on the development of sensors and sensor networks that leverage the tools created by the optical telecommunication industry for industrial applications. As the VP of PSI’s Applied Optics and Sensor Applications business areas, he is the PSI technical and business lead in developing a number of instrumentation technologies focused on pharmaceutical manufacturing, including: • Tunable Diode Laser Absorption Spectroscopy (TDLAS) based LyoFlux water vapor mass flow rate sensor for lyophilization monitoring/control; • Optical Coherence Tomography/Freeze Drying Microscopy instrument for determination of product formulation critical temperatures; • TDLAS SMART Freeze Dryer automated process development/control technology; • Miniature 7-Vial Lyophilizer for scale-up/scale-down R&D; • Solvent vapor monitor for fluid bed spray coating operations; • VPHP sensor for barrier isolator decontamination. Bill continues R&D focused on pharmaceutical lyphilization, including the development of modeling tools and automated process development and control algorithms.
For more information, contact: Robin Bogner at robin.bogner@uconn.edu