MCB Seminar Series: Dr. Bill Royer, UMass Medical School
Host: Dr. Robinson
"Oncogenic C-terminal Binding Protein (CtBP) Assembly and Inhibitor design"
Summary: C-terminal Binding Protein (CtBP1 and 2) is a co-transcriptional factor whose activity is linked with a broad range of cancers. We are developing active site inhibitors which disrupt the tetrameric assembly and oncogenic activity of CtBP2
About Dr. Royer: Dr, Royer received his PhD in Biophysics at Johns Hopkins University in 1984, then carried out post-doctoral work in Wayne Hendrickson’s lab at Columbia University before starting a faculty position at UMass Medical School in 1990. His research has focused on the structural basis for the coupling between assembly and protein function. Work from his lab has revealed unique mechanisms for allosteric behavior in a variety of hemoglobins, details of the interactions of the pathogenic deoxy sickle-cell hemoglobin fiber and the mechanism for the phosphorylation induced activation of interferon regulatory factors. Their current work involves the investigation of NAD(H) activation of the co-transcriptional factor CtBP and the design of inhibitors that interfere with assembly and oncogenic activity.
Publications:
https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/04/Jecrois_cryoEM_2020.pdfhttps://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/04/FEBS-Letters-2022-Erlandsen-NADH-NAD-binding-and-linked-tetrameric-assembly-of-the-oncogenic-transcription-factors-2.pdfRoyer Lab website