The Department of Pharmaceutical Sciences invites you to attend an H.G. Hewitt Drug Discovery seminar on Monday, May 6, 2019, from 3:30pm - 4:30pm, Engineering and Science Building (ESB), room 121
Seminar speaker: Tomasz Cierpicki, Ph.D., Associate Professor, Department of Pathology, University of Michigan
Seminar title: "Targeting Protein-Protein Interactions in Cancer"
Education:
- MSc in chemistry: Department of Chemistry; Wroclaw University of Technology; Poland
- PhD in biochemistry: Department of Biochemistry and Molecular Biology; University of Wroclaw; Poland
- Postdoctoral fellow: University of Virginia, Charlottesville, VA
- Assistant Professor in the Department on Pathology, University of Michigan (2009-2016)
- Associate Professor in the Department of Pathology, University of Michigan (since 2016)
Research Overview
The research in Dr Cierpicki’s laboratory is focused on structural and chemical biology of proteins in cancer. We are interested in understanding the molecular basis leading to acute leukemia and in development of small molecules which could reverse the effect of leukemia oncoproteins. One of the current projects in my laboratory is development of small molecule inhibitors targeting BMI-1 oncoprotein. We are using broad range of biochemical, biophysical and structural biology methods (NMR and X-ray crystallography) in combination with medicinal chemistry to support development of potent inhibitors. In collaboration with Dr. Jolanta Grembecka we are developing small molecules targeting menin-MLL interaction to reverse the oncogenic potential of MLL fusion oncoproteins.
For more information, contact: Dr. M. Kyle Hadden at 860-486-8446